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dc.contributor.authorSantos, Érica Mendes dos-
dc.contributor.authorMacedo, Lucas Malvezzi de-
dc.contributor.authorAtaide, Janaína Artem-
dc.contributor.authorDelafiori, Jeany-
dc.contributor.authorGuarnieri, João Paulo de Oliveira-
dc.contributor.authorRosa, Paulo César Pires-
dc.contributor.authorRuiz, Ana Lucia Tasca Gois-
dc.contributor.authorLancellotti, Marcelo-
dc.contributor.authorJozala, Angela Faustino-
dc.contributor.authorCatharino, Rodrigo Ramos-
dc.contributor.authorCamargo, Gisele Anne-
dc.contributor.authorSantos, Ana Cláudia Paiva-
dc.contributor.authorMazzola, Priscila Gava-
dc.date.accessioned2025-08-14T11:48:49Z-
dc.date.available2025-08-14T11:48:49Z-
dc.date.issued2024-
dc.identifier.urihttp://repositorio.ital.sp.gov.br/jspui/handle/123456789/841-
dc.description.abstractConsumer demand for natural, chemical‑free products has grown. Food industry residues, like coffee pulp, rich in caffeine, chlorogenic acid and phenolic compounds, offer potential for pharmaceutical and cosmetic applications due to their antioxidant, anti‑inflammatory, and antibacterial properties. Therefore, the objective of this work was to develop a phytocosmetic only with natural products containing coffee pulp extract as active pharmaceutical ingredient with antioxidant, antimicrobial and healing activity. Eight samples from Coffea arabica and Coffea canephora Pierre were analyzed for caffeine, chlorogenic acid, phenolic compounds, tannins, flavonoids, cytotoxicity, antibacterial activity, and healing potential. The Robusta IAC—extract had the greatest prominence with 192.92 μg/ mL of chlorogenic acid, 58.98 ± 2.88 mg GAE/g sample in the FRAP test, 79.53 ± 5.61 mg GAE/g sample in the test of total phenolics, was not cytotoxic, and MIC 3 mg/mL against Staphylococcus aureus. This extract was incorporated into a stable formulation and preferred by 88% of volunteers. At last, a scratch assay exhibited the formulation promoted cell migration after 24 h, therefore, increased scratch retraction. In this way, it was possible to develop a phytocosmetic with the coffee pulp that showed desirable antioxidant, antimicrobial and healing properties.pt_BR
dc.description.sponsorshipCAPES, CNPq, FAPESP, FUNCAMPpt_BR
dc.language.isoen_USpt_BR
dc.publisherSpringerpt_BR
dc.subjectAntioxidant,pt_BR
dc.subjectAntimicrobialpt_BR
dc.subjectBy-productspt_BR
dc.subjectCoffeept_BR
dc.subjectPhytocosmeticpt_BR
dc.subjectWound healingpt_BR
dc.titleAntioxidant, antimicrobial and healing properties of an extract from coffee pulp for the development of a phytocosmeticpt_BR
dc.typeArticlept_BR
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