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dc.contributor.authorNascimento, Edilza Silva do-
dc.contributor.authorPacheco-Bertoldo, Maria Teresa-
dc.contributor.otherPT_Br
dc.date.accessioned-
dc.date.accessioned2022-09-13T19:55:38Z-
dc.date.availablePT_Br
dc.date.available2022-09-13T19:55:38Z-
dc.date.copyright-
dc.date.issued2021-
dc.identifierPT_Br
dc.identifier.citationFOOD RESEARCH INTERNATIONAL, v. 143, p. 110286, 2021. https://doi.org/10.1016/j.foodres.2021.110286.pt_BR
dc.identifier.urihttp://repositorio.ital.sp.gov.br/jspui/handle/123456789/450-
dc.description.abstractBioactive peptides have been broadly studied for their contribution to human health. This study aimed to identify bioactive peptides generated by in vitro gastrointestinal digestion of yam proteins. Yam protein concentrate (YPC) was submitted to simulated digestion. Gastric phase hydrolysate (GPH) and total gastrointestinal phase hydrolysate (GIPH) had their peptides identified by nanoLC-ESI-MS/MS. Peptide sequences were subjected to a database-driven (BIOPEP) bioactivity search. In vitro tests included: Antioxidant activity, DNA damage protection, ACE-inhibitory activity and antibacterial activity against the bacteria Escherichia coli, Salmonella sp. and Lysteria monocytogenes. Simulated digestion generated small peptides (mostly MW < 3500 Da), several of them with potential bioactive sequences predicted in silico. In both GPH and GIPH biological activities were detected, although GIPH displayed stronger DNA damage protection and antibacterial activity against Escherichia coli. The digestion of yam proteins releases promising biologically active peptides which can contribute to the prevention of bacterial infection and chronic degenerative diseases, with beneficial effects to human health.pt_BR
dc.description.sponsorshipFAPESP / CNPqpt_BR
dc.formatPT_Br
dc.languagePT_Br
dc.language.isoenpt_BR
dc.publisherElsevierpt_BR
dc.rightsPT_Br
dc.sourcePT_Br
dc.subjectBIOPEPpt_BR
dc.subjectNanoLC-ESI-MS/MSpt_BR
dc.subjectBioactive potentialpt_BR
dc.subjectAngiotensin I-Converting Enzyme (ACE)pt_BR
dc.subjectinhibitory activitypt_BR
dc.subjectAntibacterial activitypt_BR
dc.subjectAntioxidant activitypt_BR
dc.titleIdentification of bioactive peptides released from in vitro gastrointestinal digestion of yam proteins (Dioscorea cayennensis)pt_BR
dc.typeArticlept_BR
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dc.subject.cnpqPT_Br
dc.contributor.CRUESPPT_Br
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